Innovation has been the lifeblood of the Cleveland Clinic since 1921, when it was founded by physicians who imported practices learned in World War I. Cleveland Clinic has been home to numerous medical breakthroughs – from the first successful coronary artery bypass surgery to the first face transplant in the U.S. In 2023, it became home to the world’s first quantum computer dedicated to healthcare research.

Self-Cleaning Technology™ in a paint? Yes, it’s real – and it was created right here in Cleveland. Sherwin-Williams has been bringing color, creativity and innovative products such as this to the world for more than 155 years.  Founded in 1866, the Cleveland company has grown into a global leader in the manufacture, development, distribution, and sale of paint, coatings and related products.

Nottingham Spirk may not be a household name – but their inventions are likely in your house. Have a Dirt Devil vacuum? Arm & Hammer Spinbrush or Swiffer Sweep + Vac? These are just a few of the 1,400 patented products the design collaborative has created for clients in the consumer, business and health-care sectors. Generating more than $50 billion in sales, these Cleveland disrupters are global leaders in growth-propelling innovation.

The numbers tell the impressive story when it comes to Cleveland-based Park Place Technologies. Supporting data centers in more than 180 countries – including more than 1 million assets for over 21,000 customers – Park Place is experiencing remarkable development, named to CRN’s Fast Growth 150 list for nine years. Now that’s good data.

Cleveland-Cliffs is proud to produce some of the most advanced steel in the world. From building cities to being a global leader in automotive-grade steel – including the innovation driving the EV revolution – Cleveland Cliffs has been making America strong since 1847. The largest flat-rolled steel company in North America – with more than $23 billion in revenue in 2022– they are committed to quality, innovation and being a leader in environmental sustainability.

A World Enlightened by Reading – a simple yet profound goal. OverDrive created the world’s largest digital service for libraries and schools. The Cleveland digital book company serves 91,000 libraries and schools in 113 countries with their Libby and Sora apps – now that’s something worth reading about!

For more than 150 years, University Hospitals of Cleveland has made the region and world healthier through awe-inspiring research and innovation -- from breakthroughs in CPR and minimally invasive heart surgery to revolutionary limb salvage and amputation prevention vascular surgery.

With 90% of the parts made in Cleveland, this unique ride is truly “LANDmade.” Founded in 2020, LAND has quickly become one of the most innovative electric vehicle companies in the country, producing their signature District eMoto bike, a two-wheeler that melds the concepts of eBikes, eMopeds and eMotorcycles. It’s a sweet ride from Cleveland, for the world.

With products found in more than 80 % of American Homes, the Orrville-based J.M. Smucker Company is like part of the family. Founded in 1897 when it sold apple butter, today Smucker is a Fortune 500 company with a broad portfolio of brands people and pets love. In addition to its namesake fruit spreads, Smucker offers Jif® peanut butter, Smucker’s® Uncrustables® frozen handheld sandwiches, Folgers® coffee, Milk-Bone® dog treats, Meow Mix® cat food and Hostess® sweet baked snacks.

One of only 10 major NASA facilities, Glenn Research Center has been integral in many of NASA’s most famous missions. Today, with more than 3,000 employees, it is providing integral support to the Artemis 1 mission, overseeing the service module that will propel the Orion space capsule out of earth's orbit and around the moon. Glenn also played important roles in the Mercury and Apollo missions, the Space Shuttle, the International Space Station and Mars rovers. Now THAT is out of this world! 

No need to travel to Paris or Milan for the latest runway ready looks. Greater Cleveland’s Gordon Square is where you’ll find Yellowcake, the signature line of women’s outerwear and accessories by artist and Project Runway alumna Valerie Mayén. It’s luxury clothing for modern women.

Good food, good life: that’s the mission of Nestle. You may know them for their delicious croissant crust pizzas and hundreds of other food innovations. But that’s just a small taste of the world’s largest food and beverage company, selling products in 188 countries. With a focus on nutrition and sustainability, they are meeting consumer needs through innovation – and, yes, making good food.

Avient’s purpose is to be an innovator of materials solutions to help customers succeed, while enabling a sustainable world. From next-generation energy infrastructure to self-administered healthcare devices to life-saving armor, Avient provides engineered polymer formulations, colorants, functional additives and other materials that transform bold visions into realities. As an industry leader based in Avon Lake, Ohio, Avient combines global reach, a diverse technology portfolio, and a culture of safety and sustainability to collaborate with brand owners on solving the toughest materials challenges.

Since 1947, Solon-based Swagelok has innovated new ways to help customers around the world safely, efficiently and reliably move pressurized liquids and gases in demanding applications. By applying a deep understanding of customers’ applications and evolving requirements, they're constantly finding new solutions to the world's industrial fluid handling challenges.

Cleveland Kitchen has an innovative culinary mission: creating world-class fermented foods for all while delivering gut-health benefits by the forkful. From their early days of slinging fresh, crunchy Sauerkraut at farmers markets to pioneering the fresh fermented category within produce and crafting the No. 1 Kimchi in America, Cleveland Kitchen has been inspired by the longtime tradition, flavors and health benefits of fermentation. 

For more than 75 years, GOJO, Makers of PURELL™, has been powered by people energized by helping the world experience greater health and well-being. Through its science-based innovation, GOJO continues to set new standards for the safety, effectiveness and sustainability of PURELL® hand and surface hygiene products that hospitals, businesses, and people worldwide use daily.

At Case Western Reserve University, students, faculty, researchers and graduates think big. But they don’t just think – they do. From education and research at the University Circle campus to the work of 120,000+ alumni around the world, CWRU is dedicated to innovation, discovery – and, most importantly, making a difference in the world.

Among professional chefs and home cooks, Vitamix blenders have a reputation for being the best. And year after year, that reputation is backed up by independent testers like Wirecutter, America's Test Kitchen, Epicuriousand others. These industry-defining blenders break down any ingredient into healthy, delicious smoothies, soups and much more. Plus, they’re engineered to last up to 10x longer than an average blender.

Lubrizol is a global, market-focused innovator of breakthrough science-based solutions that advance mobility, improve wellbeing and enhance modern life.

Founded by the Mueller family in 1918, Dealer Tire is steeped in a century of integrity and innovation. Betting on market opportunity, the company focused its efforts on the growing needs of the automotive dealers, evolving from a single store to an international distributor of tires and parts.

Opened in 1916 "for the benefit of all people, forever,” the Cleveland Museum of Art is renowned for its collection, which includes more than 63,000 artworks and spans 6,000 years of achievement in the arts. The museum is a significant international forum for exhibitions and scholarship and is a leader in digital innovations and conservation.

Parker, a Fortune 250 leader in motion and control technologies, has been helping things move – and solving complex engineering challenges - for more than a century. Innovations such as the Ebrake®, a groundbreaking brake-by-wire system, are integrated into everything from industrial machinery to aircraft. With operations in 45 countries and a distribution network spanning 17,000 locations, Parker delivers its cutting-edge solutions worldwide.

DayGlo Color Corp. is the world’s largest manufacturer of daylight fluorescent pigments, offering a wide range of innovative technologies to enhance and transform colors—from radiant fluorescent colors to subtle specialty effects, and glow-in-the-dark pigments. With roots in science and a passion for exploring the possibilities of color, DayGlo pushes the boundaries of what color can do.

For more than 90 years, Medical Mutual has been a trusted healthcare partner, delivering innovative solutions to businesses across Cleveland.